Oxford Colloid Group

Microfluidic devices are a powerful tool in biological sciences. Different microfluidic techniques have contributed to the improvement of existing biological assays and to the development of novel quantification methods. Droplet-based microfluidics is a technique that is becoming increasingly important for various applications such as single cell analysis, complex biochemical assays, drug screening and directed evolution experiments. 

Micro-droplets can be considered as very small reactors with volumes of the order of a picolitre, which can be generated and manipulated in different ways. Various components can easily be encapsulated upon droplet formation and additional reagents can be added post-formation. In collaboration with the group of Prof. John Frater in the Nuffield Department of Medicine in Oxford we are applying droplet-based microfluidics techniques study of HIV-1 infection, and are currently setting up a system to sort rare HIV-1 infected cells encapsulated in droplets. These cells are particularly interesting since they persist during antiretroviral therapy and are the major obstacle to the eradication of the virus. Recently, we have also begun applying microfluidics to the study of Covid-19.

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Last updated 21/01/2022.